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Angelini Pharma Italia, historically known as A.C.R.A.F. (Aziende Chimiche Riunite Angelini Francesco), is the core Italian pharmaceutical operating company within Angelini Pharma and part of privately held Angelini Industries. The business researches, develops, manufactures, and commercializes medicines and health products with a strategic focus on brain health, including epilepsy and mental health, alongside specialty and primary care and consumer healthcare. Its marketed portfolio includes products such as Ontozry (cenobamate), Latuda (lurasidone), and Trittico (trazodone), and it also operates manufacturing assets for finished pharmaceuticals and active pharmaceutical ingredients. Through Angelini Fine Chemicals, the company also provides small-molecule development and manufacturing services to external pharmaceutical and biotech customers. Overall, A.C.R.A.F. is best understood today as the legacy legal name behind Angelini Pharma Italia rather than a standalone venture-stage biotech.
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