Apple-Tree

Apple Tree Partners (ATP) is a premier life sciences venture capital firm and biotech incubator that specializes in creating and building transformative biotechnology companies. Founded in 1999 by Dr. Seth Harrison, the firm utilizes a unique 'venture build' model, initiating companies from pre-IP concepts or academic spinouts and providing extensive in-house R&D support through its ATP R&D unit. ATP's portfolio encompasses approximately 30 companies focused on diverse therapeutic areas, including oncology, metabolic disorders, ophthalmology, and infectious diseases, employing advanced modalities such as RNA editing, self-replicating RNA, and AI-driven small molecule discovery. In December 2025, the firm filed for Chapter 11 bankruptcy protection to facilitate a strategic reorganization amid a governance dispute with its primary investor, while maintaining ongoing operations and support for its portfolio biotechs.