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Atopix Therapeutics developed oral CRTH2 antagonists for allergic and eosinophilic diseases, with its lead candidate timapiprant showing efficacy in asthma and allergic rhinoconjunctivitis in over 800 patients and demonstrating an excellent safety profile. The company focused on Th2-mediated eosinophilic asthma, targeting the CRTH2 receptor to interfere with allergic inflammation without broad immunosuppression.
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