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Avant Immunotherapeutics, Inc.
Needham, Massachusetts, United Statescelldextherapeutics.com ↗
- Ownership
- Private
- Development stage
- Other
01
Overview
Avant Immunotherapeutics developed a portfolio of therapeutic vaccines and immunotherapies targeting infectious diseases and cancers. Notable results included strong immunogenicity for its single-dose oral Ty800 typhoid vaccine (>90% immune response in Phase I/II) and advancement of CDX‑110 for glioblastoma into Phase II with Pfizer partnership. The company merged with Celldex Therapeutics in early/mid‑2008, after which it operated under the Celldex name.[4][6][8]
- Therapeutic areas
- OncologyInfectious Diseases
- Modalities
- Therapeutic vaccinesMonoclonal antibodies (mAbs)Immunomodulators[4][8]
- Industry
- Biotech
02
Partnerships
Pfizer – exclusive worldwide license for CDX‑110 therapeutic brain cancer vaccine candidate; also equity investment and milestone payments agreement[8]National Institute of Allergy and Infectious Diseases/National Institutes of Health – funding/support for Ty800 development/trials[6]Academic collaborations with Johns Hopkins University, Duke University Brain Tumor Center, MD Anderson Cancer Center on GBM program/CDX‑110 development[8]
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