AVS Companies

Amplitude Vascular Systems (AVS) is a clinical-stage medical device company focused on the treatment of severely calcified arterial disease. The company's flagship technology, the Pulse IVL (Intravascular Lithotripsy) System, utilizes a novel pulsatile mechanism to shatter calcium in both peripheral and coronary arteries, aiming to improve vessel compliance and blood flow. AVS is currently conducting the POWER-PAD-II pivotal trial for its peripheral application and is expanding its platform to address coronary and carotid indications. Backed by investors such as BioStar Capital and Cue Growth Partners, AVS is positioned as a key innovator in the rapidly growing intravascular lithotripsy market. The company recently expanded its global headquarters in Waltham, Massachusetts, to support its transition toward commercialization.