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Axon Therapies

Santa Clara, California, United Statesaxontherapies.com ↗

Ownership: Private
Development stage: Phase 2

Overview

Axon Therapies has developed a minimally invasive, implant-free catheter-based procedure called Splanchnic Ablation for Volume Management (SAVM), targeting the greater splanchnic nerve to modulate sympathetic nervous system activity—a root cause of heart failure progression. Early clinical results from the REBALANCE-HF feasibility IDE trial show safety and efficacy signals, including improvements in pulmonary capillary wedge pressure during exercise and patient quality of life. Pilot studies demonstrated a durable effect at one year.

Therapeutic areas: Cardiovascular
Modalities: Device (catheter-based ablation system)Non-pharmacological therapy (minimally invasive procedure)
Industry: Surgical Medical Devices

Drug pipeline

1 asset

Axon Ablation System

Phase 2

Indications: Heart failure with preserved ejection fraction

Partnerships

Confidential strategic investor(s)no major disclosed pharma/biotech partnerships as of June 2025

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