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Be Biopharma has initiated a Phase 1/2 trial ("BeCoMe‑9") for its lead candidate BE‑101 in hemophilia B after receiving IND clearance and FDA Fast Track designation. Preclinical data for its second candidate, BE‑102 for hypophosphatasia, have been announced. The company’s BCM platform enables durable, titratable expression of therapeutic proteins via engineered human B cells without preconditioning. Both programs aim to address high unmet needs with potentially best-in-class genetic medicines.
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