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BioNumerik Pharmaceuticals focuses on the discovery and development of oncology drugs. Its lead candidate Tavocept (BNP7787/dimesna) reached Phase III trials for advanced lung adenocarcinoma and small cell carcinoma. Tavocept aims to improve survival and reduce chemotherapy toxicity by targeting thioredoxin/glutaredoxin systems. Another candidate, BNP1350/Karenitecin, was in phase II/III for NSCLC and ovarian cancer but appears discontinued. The company’s pipeline has seen mixed results with some programs discontinued or pending further data.
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