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Bitterroot Bio develops immunotherapies for cardiovascular disease by targeting immune system dysfunction underlying atherosclerosis and vascular inflammation. Its lead program, BRB‑002, targets the CD47/SIRPα pathway to promote efferocytosis and reduce plaque buildup. The company has completed preclinical efficacy/safety studies in animal models and plans to enter clinical trials soon. Series A funding ($145M) will support advancement through Phase 1/2a trials.
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