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Phase 1 trial of delNS/E6E7 for HPV-induced cervical lesions demonstrated >80% elimination of precancerous lesions with HPV clearance and excellent safety profile. Phase 1 trial for HPV-positive oropharyngeal cancer (BS03) shows strong CD8+ and CD4+ T-cell infiltration and PD-L1 upregulation, supporting combination strategies with checkpoint inhibitors.
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