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Blueprint Medicines is a commercial-stage biopharmaceutical company with two approved kinase inhibitors: avapritinib for PDGFRA exon 18-mutant gastrointestinal stromal tumor and systemic mastocytosis, and pralsetinib for RET-altered cancers (marketed via partners). It has demonstrated strong AYVAKIT/AYVAKYT efficacy in advanced and indolent systemic mastocytosis and continues to generate long-term data in indolent systemic mastocytosis while advancing next-generation KIT inhibitors and additional mast-cell and CDK-targeted programs through early and late clinical development.[1][2][5]
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