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BOOST Pharma has developed BT-101, an allogeneic mesenchymal stem cell therapy for osteogenesis imperfecta. In preclinical models and early human studies, BT-101 demonstrated increased bone formation and safety. The Phase I/II BOOSTB4 trial showed positive results in children with OI Types III and IV, including improved growth curves and reduced fractures without adverse immune responses. The company is now preparing for a pivotal Phase III trial.
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