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Boundless Bio is a clinical-stage precision oncology company developing therapies targeting extrachromosomal DNA (ecDNA) in oncogene-amplified cancers. Its lead program BBI‑355 targets Chk1 and has entered Phase 1 trials. BBI‑825, targeting ribonucleotide reductase, is also in Phase 1. A novel kinesin degrader program has selected its development candidate BBI‑940 with IND submission planned for the first half of 2026. The company recently prioritized its portfolio to focus on combination therapy approaches and extended its cash runway into the first half of 2028.
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