Company intelligence / Profile preview

BrickBio

Woburn/Boston area, Massachusetts, United Statesbrickbio.com ↗
Ownership
Private
Employees
~4
Development stage
Preclinical
01

Overview

BrickBio has demonstrated strong preclinical results with its ADCs. Its lead candidate BRKB‑28 showed potent efficacy against breast and gastric cancers in vitro without affecting healthy cells. The company recently reported a fivefold increase in the therapeutic window of a PBD-based ADC targeting B7-H3/CD276 with complete tumor eradication in animal models.[9][10] No clinical-stage assets are publicly disclosed as of May 2025.

Therapeutic areas
OncologyNeurology
Modalities
Antibody-drug conjugates (ADCs)Bispecific antibody conjugatesNovel protein scaffoldsProtein origami therapeuticsSynthetic virology (AAV modification)
Industry
Biotech
02

Drug pipeline

8 assets

BRKB-28

Preclinical

7 more assets in the full pipeline.

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03

Partnerships

Abcam – partnership to incorporate conjugation-ready sites into recombinant antibodies across Abcam’s portfolio[4].Large pharmaceutical company for co-development of ADCs [6].*(Additional pharma partnerships implied but not all partners named.)*

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