Buckle

Buckle Therapeutics is a private biotechnology company developing a patented buccal drug delivery platform designed to enable rapid, needle-free systemic delivery of critical medicines through the inner cheek. The company is focused on acute and rescue-use settings where speed, reliability, and ease of administration are important, and it positions its approach as an alternative to injections, nasal sprays, and oral pills. Its lead programs include buccal naloxone for opioid overdose reversal and buccal epinephrine for allergic reactions and anaphylaxis. Buckle also describes broader platform applicability across additional urgent-care and episodic indications such as seizure management, acute migraine, nausea and emesis, and pediatric pain and fever. The company appears to be an early-stage platform-focused drug delivery biotech rather than a traditional target-based therapeutic developer.