Caldera Pharmaceuticals

Caldera Pharmaceuticals is a biotechnology company focused on the discovery and development of novel small molecule therapeutics for oncology. Headquartered in Los Alamos, New Mexico, the company utilizes a proprietary platform to identify compounds that target specific protein conformations, particularly inactive states of kinases. This conformation-sensitive approach aims to produce inhibitors with superior selectivity and the potential to overcome resistance encountered by traditional ATP-competitive drugs. The company's research efforts have historically centered on high-value targets such as BRAF and EGFR. Caldera has been supported by various federal research grants and maintains a close relationship with the scientific community in the Los Alamos region.