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Carisma Therapeutics

Philadelphia, Pennsylvania, United States
Ownership
Public · CARM
Employees
~40
Development stage
Other
01

Overview

Carisma's liver fibrosis program (CT-2401) has achieved preclinical proof of concept, showing anti-fibrotic activity in mouse models[1]. Its oncology program (CT-1119) reached IND-enabling/preclinical stage, planning a Phase 1 trial in China before operations were paused[1]. The Moderna collaboration yielded robust preclinical anti-tumor activity for CAR-M therapies targeting glypican-3, with 12 targets nominated, but Carisma will no longer conduct further R&D on this partnership[1].

Therapeutic areas
OncologyGastroenterology
Modalities
Cell therapyCAR-macrophage therapyCAR-monocyte therapymRNA-based drugsLipid nanoparticle delivery therapy
Industry
Biotech
02

Drug pipeline

21 assets

oportuzumab monatox

3

20 more assets in the full pipeline.

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03

Partnerships

Moderna (CAR-M collaboration for oncology, now terminated for funding but milestone/royalty rights remain)[1]

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