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Agili-C, a bi-phasic, cell-free, off-the-shelf osteochondral scaffold, has demonstrated statistically significant improvements in pain, function, and MRI/clinical outcomes vs. standard surgical care in one of the largest clinical trials for cartilage lesions; it is CE-marked and FDA approved, available commercially as of 2023, with evidence of durable benefit across lesion sizes and mild to moderate osteoarthritis[2][7].
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