Castle IRB

Castle IRB was a specialized independent institutional review board focused on ethical review and oversight of human-subject research, with particular emphasis on gene and cell therapy clinical trials. The organization provided IRB review and related compliance support for sponsors, investigators, and research institutions, aiming to protect participant rights and welfare while enabling efficient study startup and conduct. Its domain expertise appeared concentrated in advanced therapies and complex clinical research areas such as oncology, infectious diseases, and rare disease. As of 2026, Castle IRB is no longer operating as a standalone brand and has been merged with Alpha IRB to form Sabai IRB under Sabai, LLC.