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Ceregene advanced multiple AAV-based gene therapies into clinical trials for major neurodegenerative diseases. CERE‑120 reached Phase 2 in Parkinson's but did not meet efficacy endpoints versus control, though it was safe and well-tolerated. CERE‑110 for Alzheimer’s entered a multi-center Phase 2 trial with NIH support; early studies showed safety but efficacy was unproven at the time of reporting[6][9]. Other programs remained preclinical or were discontinued.
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