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Checkmate Pharmaceuticals

Cambridge, Massachusetts, United Statesinvestor.regeneron.com ↗

Ownership: Private
Employees: ~31
Development stage: Phase 1

Overview

Checkmate Pharmaceuticals developed vidutolimod/CMP‑001, a next-generation TLR9 agonist delivered as a virus-like particle. In clinical trials, vidutolimod showed promising activity in PD‑1 blockade-refractory melanoma with RECIST response rates of ~20% as monotherapy and ~23.5% when combined with pembrolizumab. The combination also demonstrated durable responses with median duration exceeding two years in some patients. The company expanded development into additional solid tumor indications including HNSCC, CSCC, and MCC before being acquired by Regeneron.[8]

Therapeutic areas: Oncology
Modalities: Large molecules (biologics)Virus-like particles (VLPs)CpG-A oligonucleotides (TLR9 agonists)
Industry: Biotech

Drug pipeline

1 asset

vidutolimod

Phase 1

Indications: Melanoma, Non-melanoma skin cancers, Head and neck cancer

Partnerships

Regeneron Pharmaceuticals—clinical supply agreement to evaluate combinations with Libtayo®(cemiplimab); later acquired the company outright.Sanofi—via Libtayo® co-development partnership through Regeneron/Sanofi collaboration.Pembrolizumab/nivolumab partnerships are investigator/supply-based rather than formal corporate alliances.

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