Company intelligence / Profile preview

Cirius Therapeutics

San Diego, California, USAciriustx.com ↗
Ownership
Private
Employees
~50
Development stage
Phase 3
01

Overview

Cirius Therapeutics’ lead candidate, azemiglitazone potassium (MSDC‑0602K), has completed a Phase IIb trial in patients with MASH and type 2 diabetes. Data presented in June 2024 showed that azemiglitazone may preserve lean muscle mass when combined with GLP‑1 receptor agonists and improve metabolic parameters. The company’s approach targets the mitochondrial pyruvate carrier to reduce insulin resistance and address multiple metabolic diseases including T2D, obesity, and MASH.

Therapeutic areas
EndocrinologyCardiovascularMetabolic Disorders
Modalities
Small molecules
Industry
Biotech
02

Drug pipeline

2 assets

azemiglitazone

3

1 more asset in the full pipeline.

03

Partnerships

No major disclosed pharma partnerships as of May 2025; academic collaboration with Dr. Kyle McCommis lab at St. Louis University for preclinical research

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