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LYMPHIR™ (denileukin diftitox-cxdl) received FDA approval in August 2024 for relapsed or refractory cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy. Phase 1 trials in solid tumors (combination with pembrolizumab) show a 27% objective response rate and 33% clinical benefit rate with a median progression-free survival of 57 weeks and a favorable safety profile.
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