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Citysearch

Cambridge, MA, United States

Ownership: Private
Development stage: Other

Overview

City Therapeutics is a Cambridge-based biopharmaceutical company specializing in the development of next-generation RNA interference (RNAi) therapies. Launched in 2024 with $135 million in Series A funding, the company utilizes a proprietary engineering platform to design small interfering RNAs (siRNAs) with enhanced delivery and efficacy profiles. Its lead candidate, CITY-FXI, targets Factor XI to provide a safer anticoagulation option for patients with thromboembolic diseases. Additionally, City Therapeutics has established a significant research collaboration with Biogen to apply its RNAi technology to central nervous system disorders. The company is led by industry pioneers, including former Alnylam CEO John Maraganore, and aims to expand the reach of RNAi medicines to previously inaccessible tissues.

Therapeutic areas: CardiovascularNeurology
Modalities: RNA interferenceSmall interfering RNA
Industry: Biotech

Partnerships

Biogen

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