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Cleara Biotech has optimized two lead development candidates, CL04177 and CL04183, which selectively eliminate 'scarred' senescent cells. These candidates demonstrate favorable pharmacokinetics, tissue distribution, and efficacy in 2D cells, 3D organoids, and mouse models for metastatic colon cancer (mCRC) and triple-negative breast cancer (TNBC), countering metastatic burden.[1][2]
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