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Climb Bio is advancing budoprutug, an anti-CD19 monoclonal antibody, in Phase 2 for primary membranous nephropathy and in Phase 1 for immune thrombocytopenia and systemic lupus erythematosus. A subcutaneous formulation is in preclinical development. The company also has CLYM116, an anti‑APRIL monoclonal antibody licensed from Mabworks, currently in IND-enabling studies for IgA nephropathy. No clinical results have been published yet; preclinical data on CLYM116 are expected later in 2025.
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