Collaboration for Research in Intensive Care

The Collaboration for Research in Intensive Care (CRIC) is a prominent Danish research organization and non-profit foundation specializing in large-scale clinical trials within the field of intensive care medicine. Headquartered at Rigshospitalet in Copenhagen, CRIC coordinates international, multicenter studies designed to provide high-quality evidence for common but under-researched critical care interventions. The organization’s portfolio includes landmark trials such as CLASSIC, HOT-ICU, and SUP-ICU, which have addressed fundamental questions regarding fluid resuscitation, oxygenation targets, and stress ulcer prophylaxis. By leveraging a robust network of intensive care units across Scandinavia and Europe, CRIC aims to reduce mortality and improve long-term outcomes for critically ill patients. Their work is frequently published in high-impact journals and directly informs international clinical practice guidelines.