Combinatics

Combinatics is a Japan-based bioinformatics and software company specializing in AI-driven solutions for single-cell and spatial transcriptomics. The company's flagship platform, CellKb, is the world's largest manually curated cell type marker database, enabling automated cell type annotation, biomarker discovery, and spatial deconvolution. Combinatics also maintains HitPredict, a long-standing database for protein-protein interactions. By providing high-quality, AI-ready datasets and advanced computational tools, the company supports pharmaceutical and academic researchers in identifying therapeutic targets and understanding complex disease mechanisms. Combinatics has established partnerships with leading institutions like the University of Chicago and major pharmaceutical companies including Merck and Johnson & Johnson. The company was recognized with the Best of Show award at the 2024 Bio-IT World Expo for its innovative approach to multi-reference cell type annotation.