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CARGO Therapeutics was developing next-generation, potentially curative CAR T-cell therapies with a focus on overcoming resistance and improving durability in hematologic cancers. Its lead autologous CD22-targeted product, firicabtagene autoleucel ("firi-cel", also known as CRG‑022), reached Phase II trials in large B-cell lymphoma patients who had failed prior CD19-directed therapies. In March 2025, the company discontinued its clinical programs—including the allogeneic platform—and reduced its workforce by ~90% while seeking strategic alternatives such as a reverse merger.
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