Company intelligence / Profile preview

Constant Therapeutics LLC

Boston, Massachusetts, United Statesconstanttherapeutics.com ↗
Ownership
Private
Development stage
Other
01

Overview

Constant Therapeutics LLC develops peptide and small molecule drugs targeting the alternative renin angiotensin system. Its lead candidate TXA127 entered a phase 2 trial in March 2024 for Duchenne Muscular Dystrophy-associated cardiomyopathy. The company also pursues treatments for ischemic stroke recovery and has additional preclinical programs in metabolic and rare diseases. The company’s approach centers on activating the Mas/MrgD receptors to counteract classical RAS effects implicated in cardiovascular and metabolic disorders. Early clinical results are pending from ongoing studies.[1][5]

Therapeutic areas
CardiovascularNeurologyMetabolic Disorders
Modalities
Peptides (notably synthetic peptides)Small molecules[1][6]
Industry
Biotech
02

Drug pipeline

2 assets

talfirastide

2

1 more asset in the full pipeline.

03

Partnerships

Collaborations with Columbia University noted as sponsor/collaborator on some trials/programs.[6]

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