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Courage Therapeutics is developing novel peptides and small molecules targeting GPCRs involved in energy homeostasis. Their lead programs are preclinical candidates with potent MC4R agonist activity for obesity and MC3R antagonist/agonist activity for anorexia nervosa and binge eating disorder. The company has not yet entered clinical trials but has established a strong IP position through licensing from the University of Michigan and ongoing medicinal chemistry efforts led by Dr. Tomi Sawyer.
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