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Crescent Biopharma is developing a tetravalent bispecific PD-1 x VEGF monoclonal antibody (CR-001) for solid tumors, with IND planned Q4 2025 and proof-of-concept Phase 1 trial data expected in 2026. Two novel ADCs (CR-002, CR-003) with topoisomerase inhibitor payloads are in advanced pre-clinical development, IND for first ADC planned for mid-2026
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