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Cullinan Pearl owned the global (excluding Japan) rights to zipalertinib (CLN-081/TAS6417), an orally available, irreversible EGFR inhibitor targeting exon 20 insertions. The drug received FDA Breakthrough Therapy Designation and was in ongoing pivotal studies for NSCLC harboring EGFR exon 20 mutations at the time of acquisition. Enrollment in key pivotal modules was on track for completion by the end of 2024.
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