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Cylene Pharmaceuticals was a San Diego-based biotech company focused on developing targeted small-molecule drugs for life-threatening cancers, especially those resistant to existing therapies. Its lead technology involved inhibiting ribosomal RNA biosynthesis and targeting G quadruplex DNA structures. The most advanced candidate, CX‑3543, reached late Phase I trials for cancer but the company appears to have ceased operations with all pipeline programs either discontinued or inactive as of the latest records.
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