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Denovo Neuroscience is a clinical-stage biopharmaceutical company focused on developing precision medicines for central nervous system (CNS) disorders. The company leverages its proprietary, big-data-enabled Denovo Genomic Marker (DGM™) biomarker discovery platform to retrospectively identify genetic biomarkers from archived clinical samples, allowing them to rescue and advance previously discontinued therapies. Denovo's lead asset is DB104 (liafensine), a first-in-class triple reuptake inhibitor in Phase 3 development for treatment-resistant depression (TRD) guided by the ANK3 genetic biomarker. Its broader CNS pipeline includes DB103 (pomaglumetad methionil) for schizophrenia and psychosis, DB105 for Alzheimer's disease, and DB109 for Alzheimer's disease.
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