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DiogenX is developing a first-in-class regenerative treatment for type 1 diabetes. Its lead program uses a recombinant protein to modulate the Wnt/β-catenin signaling pathway, aiming to regenerate pancreatic insulin-producing beta cells. The company has demonstrated efficacy in preventing and reversing diabetes in preclinical models, with significant increases in functional human beta cells and good tolerability observed in long-term animal studies[4].
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