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Dialectic Therapeutics, Inc.

Dallas, Texas, United Statesdtsciences.com ↗

Ownership: Private
Development stage: Phase 1

Overview

DT2216, the company’s first-in-class compound using the APTaD™ platform to target BCL family proteins, entered a first-in-human Phase 1 dose escalation trial in patients with relapsed or refractory solid tumors and hematologic malignancies. The compound has received FDA Fast Track designation for PTCL/CTCL and Orphan Drug Designation for T-cell lymphoma. Preclinical data suggest reduced toxicity—especially to platelets—and lower risk of resistance compared to traditional chemotherapy agents.[4][5]

Therapeutic areas: Oncology
Modalities: Targeted protein degraders (specifically antiapoptotic protein targeted degradation)Small molecules (via APTaD™ platform)[4][5]
Industry: Biotech

Drug pipeline

3 assets

DT2216

2 more assets in the full pipeline.

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Partnerships

Research partners at UT Health San Antonio and University of Florida Health[4]Supported by Cancer Prevention & Research Institute of Texas grants[2][4]

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