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Door Pharmaceuticals is developing a novel class of antivirals called reactive capsid assembly modulators (rCAMs) for chronic Hepatitis B virus. The company has demonstrated that small molecules binding to HBV core protein can suppress HBV production, potentially by inhibiting viral RNA transcription. As of 2024, the company received Phase I SBIR funding ($306,500) to develop rCAMs that target viral nucleic acids for destruction by concentrating reactive components near viral DNA and RNA.
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