Dr. Claudio De Simone

Dr. Claudio De Simone is the inventor of the "De Simone Formulation," a proprietary high-concentration probiotic blend consisting of eight distinct strains of live bacteria. This formulation is recognized globally for its extensive clinical evidence in treating complex gastrointestinal and hepatic disorders, including ulcerative colitis and pouchitis. Originally sold under the brand name VSL#3, the formulation is now marketed as Vivomixx in Europe and Visbiome in North America following the expiration of licensing agreements and subsequent litigation. The business entity, often operating through Mendes S.A., focuses on the manufacturing, quality control, and clinical validation of this specific microbial therapy. The formulation is supported by over 200 peer-reviewed publications and is included in several international medical guidelines for the management of inflammatory bowel disease.