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Dren Bio

Foster City, California, United Statesdrenbio.com ↗

Ownership: Private
Employees: ~75
Development stage: Phase 1

Overview

Dren Bio’s lead clinical programs are:

DR‑01, a first-in-class antibody for selective depletion of pathogenic CD8 T cells, currently in clinical evaluation for hematologic cancers and expanding into autoimmune indications.
DR‑0201, a bispecific antibody targeting CD20 for deep B-cell depletion via myeloid cell engagement. Early clinical data show robust B-cell depletion with potential to reset the immune system. This program was acquired by Sanofi in March 2025 after promising early results.[4] The company also has multiple preclinical programs leveraging its proprietary platform across oncology, immunology, and neurology.[5]

Therapeutic areas: OncologyImmunology
Modalities: bispecific antibodiesmonoclonal antibodies (mAbs)protein engineering
Industry: Biotech

Drug pipeline

4 assets

DR-01

3 more assets in the full pipeline.

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Partnerships

Novartis Pharma AG – strategic collaboration on bispecific antibodies for cancer announced July 2024Sanofi – acquisition of DR–0201 program/affiliate March–Q2’25

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