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DuraCAR is an experimental chimeric antigen receptor T-cell (CAR-T) therapeutic platform being developed by Regen BioPharma. It targets CD19 and incorporates siRNA-mediated modulation of NR2F6 to potentially enhance immunosuppressive properties or tumor-killing activity. Preclinical studies have shown that these engineered T cells can elevate NR2F6 expression, which may suppress autoimmunity or improve anti-tumor effects. The program remains in preclinical development with ongoing validation experiments through contract research organizations.
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