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Edgewise Therapeutics is advancing a pipeline of small molecule therapies for rare and severe muscle diseases. Its lead candidate, EDG-5506 (sevasemten), is in Phase III trials for Becker muscular dystrophy and has shown promise as a first-in-class fast skeletal myosin inhibitor. EDG-7500, targeting hypertrophic cardiomyopathy, is in Phase II development. The company’s approach leverages precision medicine to modulate key muscle proteins with the goal of addressing significant unmet needs in genetically defined muscle disorders
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