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Stylus Medicine has developed a novel in vivo gene editing platform using engineered recombinases and cell-targeted lipid nanoparticles. Their approach enables precise, durable integration of large therapeutic payloads directly into patient immune cells, aiming to simplify and scale CAR-T therapies. The company is currently preclinical, with first data from a single-dose CD3-targeted LNP-CAR program expected at ASGCT 2025.
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