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Excision BioTherapeutics
Watertown, Massachusetts, United States
- Ownership
- Private
- Development stage
- Other
01
Overview
Excision BioTherapeutics has demonstrated proof-of-concept that its multiplexed CRISPR/Cas-based therapies can excise viral DNA from infected cells. Its lead candidate EBT‑101 for HIV has completed early-stage human safety studies with no major side effects reported but efficacy data not yet disclosed as of late 2023. Preclinical data for hepatitis B and herpes programs show robust reduction of viral biomarkers and effective disruption of latent reservoirs in animal models.
- Therapeutic areas
- OphthalmologyInfectious Diseases
- Modalities
- Gene therapyCRISPR-based therapyLipid nanoparticle delivery therapy (for HBV program)AAV vector gene therapy (for HIV and HSV programs)
- Industry
- Biotech
02
Drug pipeline
7 assets6 more assets in the full pipeline.
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Partnerships
Collaborations with academic labs at Temple University and UC Berkeley; technology licensed from Doudna Lab and Khalili Lab.
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