Exgenex

ExGenex is a biotechnology company dedicated to developing a next-generation delivery platform for genetic medicines, specifically targeting the central nervous system (CNS). The company's core technology involves engineering exosomes—naturally occurring extracellular vesicles—to carry therapeutic payloads such as mRNA, siRNA, and proteins across the blood-brain barrier. By utilizing directed evolution and high-throughput screening, ExGenex optimizes these vesicles for high potency and tissue-specific uptake. Their current research and development efforts are directed toward creating transformative treatments for neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Huntington's disease. The company aims to establish a versatile delivery system that overcomes the limitations of traditional viral-based gene therapies, such as immunogenicity and limited payload capacity. Based in San Diego, ExGenex is positioned at the intersection of vesicle biology and genetic medicine to address high-unmet-need neurological conditions.