Company intelligence / Profile preview

Foghorn Therapeutics

Cambridge, Massachusetts, United Statesfoghorntx.com ↗
Ownership
Public · FHTX
Employees
~100
Development stage
Other
01

Overview

Foghorn Therapeutics has advanced its lead candidate, the oral selective SMARCA2 inhibitor FHD‑909, into a Phase 1 trial for patients with SMARCA4-mutated cancers—primarily non-small cell lung cancer. Early clinical responses have been observed in other programs such as the AML study of FHD‑286 but did not meet internal efficacy thresholds to continue independently. The company’s pipeline includes several preclinical assets targeting chromatin regulatory proteins such as ARID1B, CBP, and EP300. Preclinical data support further exploration of these agents both as monotherapies and in combination regimens. The company maintains a strong cash position supporting operations into at least late 2026 or early 2027.

Therapeutic areas
Oncology
Modalities
Small molecules (inhibitors and degraders)Precision therapeutics targeting gene expression/chromatin regulatory system
Industry
Biotech
02

Drug pipeline

8 assets

camibirstat

2

7 more assets in the full pipeline.

03

Partnerships

Eli Lilly/Loxo@Lilly – strategic collaboration on oncology medicines including co-development/co-commercialization agreement for selective SMARCA2 program plus additional discovery programs from Gene Traffic Control® platform.
04

Financials

Market cap
$113.1M
Total revenue
$30.9M
Enterprise value
$-11.4M

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