Fund for the Replacement of Animals in Medical Experiments

The Fund for the Replacement of Animals in Medical Experiments (FRAME) is a UK-based scientific research charity dedicated to the development and promotion of alternatives to animal testing. Established in 1969, FRAME advocates for the "Three Rs" (Replacement, Reduction, and Refinement), with a strategic focus on the complete replacement of animal models with scientifically valid human-based methods. The organization operates the FRAME Alternatives Laboratory at the University of Nottingham, focusing on human cell culture and in vitro research. FRAME also influences policy and practice through its peer-reviewed journal, ATLA (Alternatives to Laboratory Animals), and active participation in regulatory discussions.