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Geneos Therapeutics

Plymouth Meeting, Pennsylvania, United Statesgeneostx.com ↗

Ownership: Private
Development stage: Phase 2

Overview

Geneos Therapeutics has demonstrated positive safety, immunogenicity, and efficacy results in its lead Phase 1/2 GT‑30 trial of a personalized neoantigen vaccine plus IL‑12 and pembrolizumab in advanced HCC. The study met its primary endpoints and showed objective responses including complete responses and secondary resectability. Data were published in Nature Medicine and presented at AACR 2024. Planning for a potentially registrational trial is underway.

Therapeutic areas: Oncology
Modalities: DNA-based personalized therapeutic cancer vaccines (PTCVs)DNA plasmid encoded cytokine adjuvant (IL-12)Combination with immune checkpoint inhibitors (e.g., pembrolizumab)
Industry: Biotech

Drug pipeline

8 assets

GNOS-PV02

7 more assets in the full pipeline.

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Partnerships

Inovio Pharmaceuticals – exclusive license of core DNA vaccine technology/platform [3].Personalis, Inc. – partnership on ctDNA monitoring using NeXT Personal™ assay [6].

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