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Generation Nation
Cambridge, Massachusetts, United Statesgenerationnation.org ↗
- Ownership
- Private
- Development stage
- Other
01
Overview
Generation Bio develops redosable genetic medicines using a proprietary cell-targeted lipid nanoparticle (ctLNP) system to deliver siRNA selectively to T cells. This approach aims to silence or modulate disease-driving genes in autoreactive T cells while sparing the broader immune system. The company’s pipeline focuses on high-value, historically undruggable targets implicated in T cell-driven autoimmune diseases. No clinical results yet; first IND planned for late 2026.
- Therapeutic areas
- Rare DiseasesOphthalmologyImmunologyOther
- Modalities
- Small interfering RNA (siRNA)Lipid nanoparticle delivery therapyNonviral DNA therapeutics (historically)Closed-ended DNA (ceDNA) (platform technology)
- Industry
- Biotech
02
Partnerships
Moderna – strategic collaboration since March 2023 focused on nonviral genetic medicines and ctLNP/ceDNA technologies for immune/liver targeting. Moderna has options for multiple programs using Generation Bio’s platforms.Vir Biotechnology – historical early pandemic collaboration.
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