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Gordian Biotechnology has developed a high-throughput in vivo screening platform that enables simultaneous testing of hundreds of gene therapies or targets in animal models highly representative of human disease. Their osteoarthritis program advanced dozens of hits into human ex vivo validation studies with an 80% match to screen predictions. In metabolic-associated steatohepatitis, their pooled library recapitulated 13 out of 16 known clinical outcomes. No programs have reached clinical trials yet.
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